Ser56
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Home > Phosphorylation Site Page: > Ser56  -  NFL (rat)

Site Information
SsLSVRRsYsSSSGS   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 451024

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 6 ) , phospho-antibody ( 1 , 2 , 3 , 5 , 6 ) , western blotting ( 1 , 3 , 5 , 6 )
Relevant cell line - cell type - tissue:
'brain, hippocampus' ( 1 , 2 ) , 'brain, striatum' ( 5 ) , 'neuron, hippocampal'-brain ( 3 ) , 'neuron, striatal'-brain ( 3 ) , neuron-'brain, cerebral cortex' ( 3 , 6 )

Upstream Regulation
Treatments:
(PheSe)2 ( 5 ) , 1,25D ( 1 ) , colforsin ( 6 ) , ethanol ( 2 ) , H-89 ( 5 ) , KN-93 ( 5 ) , L-NAME ( 5 ) , MK801 ( 5 ) , okadaic_acid ( 6 ) , ovariectomy ( 1 ) , quinolinic_acid ( 3 , 5 ) , staurosporine ( 5 )

References 

1

Siebert C, et al. (2017) Vitamin D3 Reverses the Hippocampal Cytoskeleton Imbalance But Not Memory Deficits Caused by Ovariectomy in Adult Wistar Rats. Neuromolecular Med 19, 345-356
28689355   Curated Info

2

Reis KP, et al. (2015) High postnatal susceptibility of hippocampal cytoskeleton in response to ethanol exposure during pregnancy and lactation. Alcohol 49, 665-74
26314629   Curated Info

3

Pierozan P, Gonçalves Fernandes C, Ferreira F, Pessoa-Pureur R (2014) Acute intrastriatal injection of quinolinic acid provokes long-lasting misregulation of the cytoskeleton in the striatum, cerebral cortex and hippocampus of young rats. Brain Res 1577, 1-10
24976581   Curated Info

4

Heimfarth L, et al. (2012) Exposure of young rats to diphenyl ditelluride during lactation affects the homeostasis of the cytoskeleton in neural cells from striatum and cerebellum. Neurotoxicology 33, 1106-16
22705628   Curated Info

5

Pierozan P, et al. (2010) Acute intrastriatal administration of quinolinic acid provokes hyperphosphorylation of cytoskeletal intermediate filament proteins in astrocytes and neurons of rats. Exp Neurol 224, 188-96
20303347   Curated Info

6

Nakamura Y, et al. (2000) Major phosphorylation site (Ser55) of neurofilament L by cyclic AMP-dependent protein kinase in rat primary neuronal culture. J Neurochem 74, 949-59
10693925   Curated Info