Lys886
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Home > Sumoylation Site Page: > Lys886  -  GluR6 (rat)

Site Information
PQAPVIVkTEEVINM   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 12004405

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 2 ) , immunoprecipitation ( 2 ) , modification-specific antibody ( 2 ) , mutation of modification site ( 1 , 2 ) , western blotting ( 2 )
Relevant cell line - cell type - tissue:
COS (fibroblast) ( 1 ) , COS7 (fibroblast) ( 2 ) , neuron-'brain, hippocampus' ( 2 )

Upstream Regulation
Treatments:
glutamic acid ( 2 ) , kainic_acid ( 2 ) , NMDA ( 2 )

Downstream Regulation
Effects of modification on biological processes:
endocytosis, induced ( 2 ) , neural plasticity ( 2 )

References 

1

Konopacki FA, et al. (2011) Agonist-induced PKC phosphorylation regulates GluK2 SUMOylation and kainate receptor endocytosis. Proc Natl Acad Sci U S A 108, 19772-7
22089239   Curated Info

2

Martin S, Nishimune A, Mellor JR, Henley JM (2007) SUMOylation regulates kainate-receptor-mediated synaptic transmission. Nature 447, 321-5
17486098   Curated Info