Lys571
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Home > Sumoylation Site Page: > Lys571  -  GLT1 (human)

Site Information
SVEEEPWkREK____   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 12004400

In vivo Characterization
Methods used to characterize site in vivo:
electrophoretic mobility shift ( 1 ) , immunoprecipitation ( 1 ) , modification-specific antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
brain cancer ( 1 ) , glioblastoma ( 1 ) , glioma ( 1 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 ) , spinal cord ( 1 ) , U-251 MG (glial) ( 1 )

Upstream Regulation
Regulatory protein:
SOD1 (human) ( 1 )

Downstream Regulation
Effects of modification on GLT1:
intracellular localization ( 1 ) , molecular association, regulation ( 1 )
Induce interaction with:
PML (human) ( 1 )

References 

1

Gibb SL, et al. (2007) A caspase-3-cleaved fragment of the glial glutamate transporter EAAT2 is sumoylated and targeted to promyelocytic leukemia nuclear bodies in mutant SOD1-linked amyotrophic lateral sclerosis. J Biol Chem 282, 32480-90
17823119   Curated Info