Tyr713
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.6.0.2
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Tyr713  -  IL4R (human)

Site Information
SLGSGIVySALTCHL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 451066

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 , 2 ) , phospho-antibody ( 1 ) , western blotting ( 2 )
Relevant cell line - cell type - tissue:
32D (myeloid) [IRS1 (mouse)] ( 1 ) , 32D (myeloid) ( 2 ) , M12 (B lymphocyte) ( 1 )

Upstream Regulation
Treatments:
IL-4 ( 2 )

Downstream Regulation
Effects of modification on IL4R:
molecular association, regulation ( 1 )
Effects of modification on biological processes:
apoptosis, inhibited ( 2 ) , cell growth, altered ( 1 )
Induce interaction with:
SHIP (human) ( 1 )

References 

1

Kashiwada M, Giallourakis CC, Pan PY, Rothman PB (2001) Immunoreceptor tyrosine-based inhibitory motif of the IL-4 receptor associates with SH2-containing phosphatases and regulates IL-4-induced proliferation. J Immunol 167, 6382-7
11714803   Curated Info

2

Zamorano J, Keegan AD (1998) Regulation of apoptosis by tyrosine-containing domains of IL-4R alpha: Y497 and Y713, but not the STAT6-docking tyrosines, signal protection from apoptosis. J Immunol 161, 859-67
9670964   Curated Info