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Home > Ubiquitylation Site Page: > Lys143  -  MKK4 (human)

Site Information
TVDEkEQkQLLMDLD   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 11998603

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
JNK1 (human) ( 1 )
sorbitol ( 1 )

Downstream Regulation
Effects of modification on MKK4:
protein degradation ( 1 )



Ahn YH, Kurie JM (2009) MKK4/SEK1 is negatively regulated through a feedback loop involving the E3 ubiquitin ligase itch. J Biol Chem 284, 29399-404
19737936   Curated Info