Ser64
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Home > Phosphorylation Site Page: > Ser64  -  SOX9 (mouse)

Site Information
EPDLKKEsEEDKFPV   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 451039

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 , 2 ) , phospho-antibody ( 2 ) , western blotting ( 1 , 2 )
Disease tissue studied:
testicular cancer ( 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
PKACA (human) ( 1 )
Treatments:
BMP2 ( 1 ) , cAMP_analog ( 1 ) , differentiation ( 2 ) , H-89 ( 1 )

Downstream Regulation
Effects of modification on SOX9:
activity, induced ( 1 )
Effects of modification on biological processes:
transcription, altered ( 1 )

References 

1

Zhao L, Li G, Zhou GQ (2009) SOX9 directly binds CREB as a novel synergism with the PKA pathway in BMP-2-induced osteochondrogenic differentiation. J Bone Miner Res 24, 826-36
19113914   Curated Info

2

Malki S, et al. (2005) Prostaglandin D2 induces nuclear import of the sex-determining factor SOX9 via its cAMP-PKA phosphorylation. EMBO J 24, 1798-809
15889150   Curated Info