Ser323
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Home > Phosphorylation Site Page: > Ser323  -  uPA (human)

Site Information
TGFGKENsTDYLYPE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 451053

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 2 , 3 ) , mutation of modification site ( 1 , 2 , 3 )
Disease tissue studied:
leukemia ( 3 ) , acute myelogenous leukemia ( 3 ) , lymphoma ( 3 ) , cancer, squamous cell carcinoma ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
PKCA (human) ( 2 )
Kinases, in vitro:
PKCA (rat) ( 2 )
Treatments:
H-7 ( 2 ) , PD98059 ( 2 ) , phorbol_ester ( 2 ) , PKCI_19-27 ( 2 ) , SB203580 ( 2 )

Downstream Regulation
Effects of modification on uPA:
intracellular localization ( 3 ) , molecular association, regulation ( 1 )
Effects of modification on biological processes:
cell adhesion, altered ( 3 ) , cell motility, altered ( 1 , 3 ) , cytoskeletal reorganization ( 1 )
Induce interaction with:
ITGA5 (human) ( 1 ) , ITGB5 (human) ( 1 )

References 

1

Vocca I, et al. (2009) Inhibition of migration and invasion of carcinoma cells by urokinase-derived antagonists of alphavbeta5 integrin activation. Int J Cancer 124, 316-25
18844213   Curated Info

2

Franco P, et al. (1998) Protein kinase C-dependent in vivo phosphorylation of prourokinase leads to the formation of a receptor competitive antagonist. J Biol Chem 273, 27734-40
9765311   Curated Info

3

Franco P, et al. (1997) Phosphorylation of human pro-urokinase on Ser138/303 impairs its receptor-dependent ability to promote myelomonocytic adherence and motility. J Cell Biol 137, 779-91
9151681   Curated Info