Lys209
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Home > Ubiquitylation Site Page: > Lys209  -  TAK1 (human)

Site Information
EGSNySEkCDVFSWG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 11956706

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 , 2 ) , mutation of modification site ( 1 , 2 ) , western blotting ( 1 , 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
IL17RD (human) ( 1 )
Treatments:
IL-1a ( 2 )

Downstream Regulation
Effects of modification on TAK1:
molecular association, regulation ( 2 ) , phosphorylation ( 1 ) , protein stabilization ( 2 )
Effects of modification on biological processes:
apoptosis, induced ( 1 ) , signaling pathway regulation ( 1 , 2 )
Induce interaction with:
MEKK3 (human) ( 2 )

References 

1

Sun X, et al. (2013) Activation of TAK1 by Sef-S induces apoptosis in 293T cells. Cell Signal 25, 2039-46
23770285   Curated Info

2

Yamazaki K, et al. (2009) Two mechanistically and temporally distinct NF-kappaB activation pathways in IL-1 signaling. Sci Signal 2, ra66
19843958   Curated Info