Ser632
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Home > Phosphorylation Site Page: > Ser632  -  eNOS (rat)

Site Information
WRRKRKEsSNTDSAG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448637

In vivo Characterization
Methods used to characterize site in vivo:
phospho-antibody ( 1 , 2 , 3 , 4 , 5 ) , western blotting ( 1 , 2 , 3 , 4 , 5 )
Relevant cell line - cell type - tissue:
kidney ( 1 , 2 , 4 ) , penis ( 3 ) , pulmonary artery ( 5 )

Upstream Regulation
Kinases, in vitro:
PKACA (human) ( 6 )
Treatments:
endothelin ( 1 ) , high-salt diet ( 2 ) , hypertension ( 5 )

References 

1

Herrera M, Hong NJ, Ortiz PA, Garvin JL (2009) Endothelin-1 inhibits thick ascending limb transport via Akt-stimulated nitric oxide production. J Biol Chem 284, 1454-60
19033447   Curated Info

2

Herrera M, Silva G, Garvin JL (2006) A high-salt diet dissociates NO synthase-3 expression and NO production by the thick ascending limb. Hypertension 47, 95-101
16344378   Curated Info

3

Musicki B, Kramer MF, Becker RE, Burnett AL (2005) Inactivation of phosphorylated endothelial nitric oxide synthase (Ser-1177) by O-GlcNAc in diabetes-associated erectile dysfunction. Proc Natl Acad Sci U S A 102, 11870-5
16085713   Curated Info

4

Lee DL, et al. (2005) Posttranslational regulation of NO synthase activity in the renal medulla of diabetic rats. Am J Physiol Renal Physiol 288, F82-90
15383397   Curated Info

5

Sasser JM, et al. (2004) Reduced NOS3 phosphorylation mediates reduced NO/cGMP signaling in mesenteric arteries of deoxycorticosterone acetate-salt hypertensive rats. Hypertension 43, 1080-5
14993198   Curated Info

6

Michell BJ, et al. (2002) Identification of regulatory sites of phosphorylation of the bovine endothelial nitric-oxide synthase at serine 617 and serine 635. J Biol Chem 277, 42344-51
12171920   Curated Info