Ser433

Site Information
THLRRRssQLKIKIP SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 450246

In vivo Characterization
Methods used to characterize site in vivo:	[32P] bio-synthetic labeling ( 3 , 5 ) , mutation of modification site ( 5 ) , phospho-antibody ( 1 , 2 ) , phosphoamino acid analysis ( 3 , 5 ) , phosphopeptide mapping ( 3 ) , western blotting ( 1 , 2 )
Relevant cell line - cell type - tissue:	'neuron, cortical' ( 1 ) , 293 (epithelial) ( 2 ) , A293 ('renal, embryonic') ( 3 ) , neuron-'brain, cerebral cortex' ( 3 )

Upstream Regulation
Kinases, in vitro:	PKCB iso2 (rat) ( 4 )
Treatments:	calphostin_C ( 2 , 3 ) , colforsin ( 3 ) , muscarine ( 2 ) , phorbol_ester ( 1 , 3 ) , Sp-cAMPS ( 1 )

References
1	Bohnsack JP, Carlson SL, Morrow AL (2016) Differential regulation of synaptic and extrasynaptic α4 GABA(A) receptor populations by protein kinase A and protein kinase C in cultured cortical neurons. Neuropharmacology 105, 124-32 26767953 Curated Info
2	Brandon NJ, Jovanovic JN, Smart TG, Moss SJ (2002) Receptor for activated C kinase-1 facilitates protein kinase C-dependent phosphorylation and functional modulation of GABA(A) receptors with the activation of G-protein-coupled receptors. J Neurosci 22, 6353-61 12151513 Curated Info
3	Brandon NJ, et al. (2000) GABAA receptor phosphorylation and functional modulation in cortical neurons by a protein kinase C-dependent pathway. J Biol Chem 275, 38856-62 10978327 Curated Info
4	Brandon NJ, et al. (1999) Subunit-specific association of protein kinase C and the receptor for activated C kinase with GABA type A receptors. J Neurosci 19, 9228-34 10531426 Curated Info
5	Kannenberg K, et al. (1999) A novel serine kinase with specificity for beta3-subunits is tightly associated with GABA(A) receptors. J Biol Chem 274, 21257-64 10409683 Curated Info