Ser432
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Home > Phosphorylation Site Page: > Ser432  -  GABRB3 (rat)

Site Information
KTHLRRRssQLKIKI   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450245

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 3 ) , phospho-antibody ( 1 , 2 ) , phosphoamino acid analysis ( 3 ) , phosphopeptide mapping ( 3 ) , western blotting ( 1 , 2 )
Relevant cell line - cell type - tissue:
'neuron, cortical' ( 1 ) , 293 (epithelial) ( 2 ) , A293 ('renal, embryonic') ( 3 ) , neuron-'brain, cerebral cortex' ( 3 )

Upstream Regulation
Kinases, in vitro:
PKCB iso2 (rat) ( 4 )
Treatments:
calphostin_C ( 2 , 3 ) , colforsin ( 3 ) , muscarine ( 2 ) , phorbol_ester ( 1 , 3 ) , Sp-cAMPS ( 1 )

References 

1

Bohnsack JP, Carlson SL, Morrow AL (2016) Differential regulation of synaptic and extrasynaptic α4 GABA(A) receptor populations by protein kinase A and protein kinase C in cultured cortical neurons. Neuropharmacology 105, 124-32
26767953   Curated Info

2

Brandon NJ, Jovanovic JN, Smart TG, Moss SJ (2002) Receptor for activated C kinase-1 facilitates protein kinase C-dependent phosphorylation and functional modulation of GABA(A) receptors with the activation of G-protein-coupled receptors. J Neurosci 22, 6353-61
12151513   Curated Info

3

Brandon NJ, et al. (2000) GABAA receptor phosphorylation and functional modulation in cortical neurons by a protein kinase C-dependent pathway. J Biol Chem 275, 38856-62
10978327   Curated Info

4

Brandon NJ, et al. (1999) Subunit-specific association of protein kinase C and the receptor for activated C kinase with GABA type A receptors. J Neurosci 19, 9228-34
10531426   Curated Info