Ser523
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus®
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Ser523  -  IFNAR1 (mouse)

Site Information
RKYSSQTsQDsGNYS   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 11927800

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , phospho-antibody ( 1 , 2 ) , western blotting ( 1 , 2 )
Disease tissue studied:
breast cancer ( 1 ) , melanoma skin cancer ( 1 )
Relevant cell line - cell type - tissue:
MEF (fibroblast) ( 1 , 2 ) , T47D (breast cell) ( 1 ) , WM2664 (melanocyte) ( 1 )

Upstream Regulation
Regulatory protein:
GCN2 (mouse) ( 1 ) , PERK (human) ( 2 ) , PERK (mouse) ( 1 ) , PKR (mouse) ( 1 )
Treatments:
amino_acid_starvation ( 1 ) , heparin sodium ( 1 ) , thapsigargin ( 1 , 2 )

References 

1

Bhattacharya S, et al. (2013) Anti-tumorigenic effects of Type 1 interferon are subdued by integrated stress responses. Oncogene 32, 4214-21
23045272   Curated Info

2

Bhattacharya S, et al. (2010) Inducible priming phosphorylation promotes ligand-independent degradation of the IFNAR1 chain of type I interferon receptor. J Biol Chem 285, 2318-25
19948722   Curated Info