Ser64
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.6.0.2
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Ser64  -  SOX9 (human)

Site Information
EPDLkKEsEEDkFPV   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 451039

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 4 ) , immunoprecipitation ( 1 , 4 ) , mutation of modification site ( 1 , 2 , 3 , 4 ) , phospho-antibody ( 2 , 3 , 4 ) , western blotting ( 1 , 2 , 3 )
Disease tissue studied:
testicular cancer ( 3 )
Relevant cell line - cell type - tissue:
3T3 (fibroblast) ( 3 ) , ATDC5 (chondrocyte) ( 1 ) , chondrocyte ( 1 ) , chondrocyte-embryo ( 2 ) , COS (fibroblast) ( 4 ) , gonad ( 3 ) , NT2 (testicular) ( 3 )

Upstream Regulation
Putative in vivo kinases:
PKACA (human) ( 4 )
Kinases, in vitro:
PKACA (human) ( 3 , 4 )
Treatments:
BW245C ( 3 ) , cAMP_analog ( 3 ) , H-89 ( 3 ) , PGD2 ( 3 )

Downstream Regulation
Effects of modification on SOX9:
intracellular localization ( 3 ) , molecular association, regulation ( 3 )
Induce interaction with:
KPNB1 (human) ( 3 )

References 

1

Coricor G, Serra R (2016) TGF-β regulates phosphorylation and stabilization of Sox9 protein in chondrocytes through p38 and Smad dependent mechanisms. Sci Rep 6, 38616
27929080   Curated Info

2

Kumar D, Lassar AB (2009) The transcriptional activity of Sox9 in chondrocytes is regulated by RhoA signaling and actin polymerization. Mol Cell Biol 29, 4262-73
19470758   Curated Info

3

Malki S, et al. (2005) Prostaglandin D2 induces nuclear import of the sex-determining factor SOX9 via its cAMP-PKA phosphorylation. EMBO J 24, 1798-809
15889150   Curated Info

4

Huang W, Zhou X, Lefebvre V, de Crombrugghe B (2000) Phosphorylation of SOX9 by cyclic AMP-dependent protein kinase A enhances SOX9's ability to transactivate a Col2a1 chondrocyte-specific enhancer. Mol Cell Biol 20, 4149-58
10805756   Curated Info