Ser65
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.7.4
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Ser65  -  Pim1 iso2 (human)

Site Information
HSHSPRHsLRHSPGS   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 1190526800

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
colorectal cancer ( 1 ) , colorectal carcinoma ( 1 ) , leukemia ( 1 ) , acute myelogenous leukemia ( 1 ) , acute monoblastic leukemia (M5a) or acute monocytic leukemia (M5b) ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
PKCA (human) ( 1 )
Kinases, in vitro:
PKCA (human) ( 1 )

Downstream Regulation
Effects of modification on Pim1 iso2:
enzymatic activity, induced ( 1 ) , protein stabilization ( 1 )
Effects of modification on biological processes:
apoptosis, inhibited ( 1 ) , cell growth, induced ( 1 )

References 

1

Takami M, Katayama K, Noguchi K, Sugimoto Y (2018) Protein kinase C alpha-mediated phosphorylation of PIM-1L promotes the survival and proliferation of acute myeloid leukemia cells. Biochem Biophys Res Commun
30017192   Curated Info