Ser472
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Home > Phosphorylation Site Page: > Ser472  -  NFL (human)

Site Information
EAKDEPPsEGEAEEE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450895

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 , 2 , 4 , 5 , 6 , 7 , 8 )
Disease tissue studied:
Alzheimer's disease ( 7 ) , breast cancer, surrounding tissue ( 1 ) , melanoma skin cancer ( 2 ) , FTLD ( 4 ) , HAM/TSP ( 6 )
Relevant cell line - cell type - tissue:
'brain, cerebral cortex' ( 4 , 7 ) , 293 (epithelial) [AT1 (human), transfection, AT1R stable transfected HEK293] ( 5 ) , breast ( 1 ) , cerebrospinal fluid ( 6 ) , HEK293T (epithelial) ( 8 ) , WM239A (melanocyte) ( 2 )

Disease / Diagnostics Relevance
Relevant diseases:
HAM/TSP ( 6 )

References 

1

Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62
27251275   Curated Info

2

Stuart SA, et al. (2015) A Phosphoproteomic Comparison of B-RAFV600E and MKK1/2 Inhibitors in Melanoma Cells. Mol Cell Proteomics 14, 1599-615
25850435   Curated Info

3

Beli P, et al. (2012) Proteomic Investigations Reveal a Role for RNA Processing Factor THRAP3 in the DNA Damage Response. Mol Cell 46, 212-25
22424773   Curated Info

4

Herskowitz JH, et al. (2010) Phosphoproteomic Analysis Reveals Site-Specific Changes in GFAP and NDRG2 Phosphorylation in Frontotemporal Lobar Degeneration. J Proteome Res 9, 6368-79
20886841   Curated Info

5

Christensen GL, et al. (2010) Quantitative phosphoproteomics dissection of seven-transmembrane receptor signaling using full and biased agonists. Mol Cell Proteomics 9, 1540-53
20363803   Curated Info

6

Alberti C, et al. (2009) Comparative study of CSF neurofilaments in HTLV-1-associated myelopathy/tropical spastic paraparesis and other neurological disorders. AIDS Res Hum Retroviruses 25, 803-9
19678766   Curated Info

7

Xia Q, et al. (2008) Phosphoproteomic analysis of human brain by calcium phosphate precipitation and mass spectrometry. J Proteome Res 7, 2845-51
18510355   Curated Info

8

Molina H, et al. (2007) Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry. Proc Natl Acad Sci U S A 104, 2199-204
17287340   Curated Info