Ser518
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Home > Phosphorylation Site Page: > Ser518  -  ICAM3 (human)

Site Information
REHQRsGsyHVREEs   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 451020

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 7 ) , mass spectrometry ( 1 , 2 , 3 , 4 , 5 ) , mutation of modification site ( 6 , 7 ) , phosphoamino acid analysis ( 7 ) , phosphopeptide mapping ( 7 )
Disease tissue studied:
leukemia ( 5 ) , acute myelogenous leukemia ( 5 )
Relevant cell line - cell type - tissue:
bone marrow ( 5 ) , HSB-2 (T lymphocyte) ( 6 ) , Jurkat (T lymphocyte) ( 1 , 2 , 3 , 4 , 7 ) , K562 (erythroid) ( 6 ) , NS-1 (B lymphocyte) ( 6 )

Upstream Regulation
Kinases, in vitro:
PKCT (human) ( 7 )
Treatments:
phorbol_ester ( 7 )

Downstream Regulation
Effects of modification on ICAM3:
activity, induced ( 7 ) , intracellular localization ( 6 )

References 

1

Mulhern D (2012) CST Curation Set: 13112; Year: 2012; Biosample/Treatment: cell line, Jurkat/calyculin_A & pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[STY])
Curated Info

2

Mulhern D (2011) CST Curation Set: 13106; Year: 2011; Biosample/Treatment: cell line, Jurkat/calyculin_A & pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[STY])
Curated Info

3

Mulhern D (2011) CST Curation Set: 13111; Year: 2011; Biosample/Treatment: cell line, Jurkat/calyculin_A & pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[STY]
Curated Info

4

Possemato A (2010) CST Curation Set: 9038; Year: 2010; Biosample/Treatment: cell line, Jurkat/calyculin_A & pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RXXp[ST] Antibodies Used to Purify Peptides prior to LCMS: Phospho-Akt Substrate (RXRXXS/T) (110B7) Rabbit mAb Cat#: 9614, PTMScan(R) Phospho-Akt Substrate Motif (RXXS*/T*) Immunoaffinity Beads Cat#: 1978
Curated Info

5

Gu T (2009) CST Curation Set: 7674; Year: 2009; Biosample/Treatment: tissue, bone marrow/untreated; Disease: acute myelogenous leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RXXp[ST]
Curated Info

6

Serrador JM, et al. (2002) A novel serine-rich motif in the intercellular adhesion molecule 3 is critical for its ezrin/radixin/moesin-directed subcellular targeting. J Biol Chem 277, 10400-9
11784723   Curated Info

7

Hayflick JS, et al. (1997) Functional mapping of the cytoplasmic region of intercellular adhesion molecule-3 reveals important roles for serine residues. J Biol Chem 272, 22207-14
9268366   Curated Info