Ser455
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Home > Phosphorylation Site Page: > Ser455  -  SREBP-2 (human)

Site Information
SIDSEPGsPLLDDAK   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 451008

In vivo Characterization
Methods used to characterize site in vivo:
electrophoretic mobility shift ( 2 ) , immunoprecipitation ( 1 ) , mutation of modification site ( 1 , 2 ) , western blotting ( 1 )
Disease tissue studied:
liver cancer ( 1 , 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
ERK1 (human) ( 2 ) , ERK2 (human) ( 2 )
Kinases, in vitro:
ERK1 (human) ( 2 ) , ERK2 (human) ( 2 )
Treatments:
IGF-1 ( 1 ) , insulin ( 2 ) , U0126 ( 1 )

Downstream Regulation
Effects of modification on SREBP-2:
sumoylation ( 1 )
Effects of modification on biological processes:
transcription, induced ( 1 , 2 )

References 

1

Arito M, et al. (2008) Growth factor-induced phosphorylation of sterol regulatory element-binding proteins inhibits sumoylation, thereby stimulating the expression of their target genes, low density lipoprotein uptake, and lipid synthesis. J Biol Chem 283, 15224-31
18403372   Curated Info

2

Kotzka J, et al. (2004) Insulin-activated Erk-mitogen-activated protein kinases phosphorylate sterol regulatory element-binding Protein-2 at serine residues 432 and 455 in vivo. J Biol Chem 279, 22404-11
14988395   Curated Info