Ser432
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.6.0.4
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Ser432  -  SREBP-2 (human)

Site Information
NQNVLLMsPPASDSG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 451007

In vivo Characterization
Methods used to characterize site in vivo:
electrophoretic mobility shift ( 1 ) , mutation of modification site ( 1 )
Disease tissue studied:
liver cancer ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
ERK1 (human) ( 1 ) , ERK2 (human) ( 1 )
Kinases, in vitro:
ERK1 (human) ( 1 ) , ERK2 (human) ( 1 )
Treatments:
insulin ( 1 )

Downstream Regulation
Effects of modification on biological processes:
transcription, induced ( 1 )

References 

1

Kotzka J, et al. (2004) Insulin-activated Erk-mitogen-activated protein kinases phosphorylate sterol regulatory element-binding Protein-2 at serine residues 432 and 455 in vivo. J Biol Chem 279, 22404-11
14988395   Curated Info