Ser329
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Home > Phosphorylation Site Page: > Ser329  -  DNAM-1 (human)

Site Information
yVNyPTFsRRPKTRV   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450987

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 2 , 3 ) , mutation of modification site ( 1 , 2 , 3 )
Disease tissue studied:
leukemia ( 2 ) , T cell leukemia ( 2 ) , mastocytoma ( 2 )
Relevant cell line - cell type - tissue:
BW5147 (T lymphocyte) ( 3 ) , Jurkat (T lymphocyte) ( 1 , 2 ) , lymphocyte-blood ( 2 ) , natural killer cell-blood ( 2 ) , P815 (mast) ( 2 ) , Raji (B lymphocyte) ( 1 ) , T lymphocyte-blood ( 1 )

Upstream Regulation
Putative in vivo kinases:
PKCA (human) ( 3 )
Treatments:
phorbol_ester ( 3 )

Downstream Regulation
Effects of modification on DNAM-1:
activity, induced ( 1 , 3 ) , molecular association, regulation ( 1 , 2 )
Induce interaction with:
ITGAL (human) ( 2 )

References 

1

Shirakawa J, Shibuya K, Shibuya A (2005) Requirement of the serine at residue 329 for lipid raft recruitment of DNAM-1 (CD226). Int Immunol 17, 217-23
15684041   Curated Info

2

Shibuya K, et al. (1999) Physical and functional association of LFA-1 with DNAM-1 adhesion molecule. Immunity 11, 615-23
10591186   Curated Info

3

Shibuya A, Lanier LL, Phillips JH (1998) Protein kinase C is involved in the regulation of both signaling and adhesion mediated by DNAX accessory molecule-1 receptor. J Immunol 161, 1671-6
9712030   Curated Info