Tyr353

Site Information
NAQEKMVySLVSVPE SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 450970

In vivo Characterization
Methods used to characterize site in vivo:	[32P] bio-synthetic labeling ( 2 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 , 2 )
Disease tissue studied:	lymphoma ( 1 ) , B cell lymphoma ( 1 )
Relevant cell line - cell type - tissue:	293 (epithelial) [Fyn (human)] ( 2 ) , 293 (epithelial) [IP3R1 (human)] ( 2 ) , 293 (epithelial) ( 1 ) , ANJ3 (T lymphocyte) ( 1 ) , DT40 (B lymphocyte) [IP3R1 (human)] ( 2 ) , DT40 (B lymphocyte) ( 1 ) , Jurkat (T lymphocyte) ( 1 )

Downstream Regulation
Effects of modification on IP3R1:	activity, induced ( 2 ) , receptor desensitization, altered ( 1 )
Effects of modification on biological processes:	transcription, altered ( 1 )

References
1	deSouza N, et al. (2007) A function for tyrosine phosphorylation of type 1 inositol 1,4,5-trisphosphate receptor in lymphocyte activation. J Cell Biol 179, 923-34 18056410 Curated Info
2	Cui J, et al. (2004) Regulation of the type 1 inositol 1,4,5-trisphosphate receptor by phosphorylation at tyrosine 353. J Biol Chem 279, 16311-6 14761954 Curated Info