Thr400
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.5.9.3
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Thr400  -  Myc (human)

Site Information
VVILKkAtAYILsVQ   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450962

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 2 , 3 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
leukemia ( 3 ) , acute myelogenous leukemia ( 3 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
PAK2 (human) ( 3 )

Downstream Regulation
Effects of modification on Myc:
molecular association, regulation ( 1 , 2 , 3 )
Effects of modification on biological processes:
carcinogenesis, inhibited ( 2 , 3 ) , cell differentiation, induced ( 3 ) , cell growth, inhibited ( 2 ) , transcription, induced ( 1 , 3 )
Induce interaction with:
DNA ( 3 )
Inhibit interaction with:
DNA ( 1 ) , MAX (human) ( 1 , 2 )

References 

1

von Eyss B, et al. (2015) A MYC-Driven Change in Mitochondrial Dynamics Limits YAP/TAZ Function in Mammary Epithelial Cells and Breast Cancer. Cancer Cell 28, 743-57
26678338   Curated Info

2

Raffeiner P, et al. (2014) In vivo quantification and perturbation of Myc-Max interactions and the impact on oncogenic potential. Oncotarget 5, 8869-78
25326649   Curated Info

3

Uribesalgo I, et al. (2011) E-box-independent regulation of transcription and differentiation by MYC. Nat Cell Biol 13, 1443-9
22020439   Curated Info