Ser409
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Home > Phosphorylation Site Page: > Ser409  -  MITF iso8 (mouse)

Site Information
KTSSRRSsMSAEETE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450265

In vivo Characterization
Methods used to characterize site in vivo:
electrophoretic mobility shift ( 1 ) , immunoassay ( 3 ) , immunoprecipitation ( 1 , 3 ) , mutation of modification site ( 1 , 2 , 3 , 4 ) , phospho-antibody ( 3 ) , western blotting ( 1 , 3 )
Disease tissue studied:
melanoma skin cancer ( 1 , 3 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 ) , 3T3 (fibroblast) ( 3 , 4 ) , A375P (melanocyte) ( 1 ) , B16 (melanocyte) ( 3 ) , BMMC (mast) ( 3 ) , heart ( 2 ) , neural crest ( 1 ) , SK-MEL28 (melanocyte) ( 1 ) , skin ( 2 )

Upstream Regulation
Putative in vivo kinases:
p90RSK (human) ( 3 , 4 )
Treatments:
IL-6 ( 3 ) , SCF ( 3 )

Downstream Regulation
Effects of modification on MITF iso8:
intracellular localization ( 1 , 3 ) , molecular association, regulation ( 3 , 4 ) , protein stabilization ( 1 )
Effects of modification on biological processes:
transcription, altered ( 3 ) , transcription, induced ( 4 )
Inhibit interaction with:
PIAS3 (human) ( 4 ) , PIAS3 (mouse) ( 3 )

References 

1

Vu HN, et al. (2023) Novel mechanisms of MITF regulation and melanoma predisposition identified in a mouse suppressor screen. bioRxiv
37786677   Curated Info

2

Bauer GL, et al. (2009) The role of MITF phosphorylation sites during coat color and eye development in mice analyzed by bacterial artificial chromosome transgene rescue. Genetics 183, 581-94
19635938   Curated Info

3

Sonnenblick A, Levy C, Razin E (2004) Interplay between MITF, PIAS3, and STAT3 in mast cells and melanocytes. Mol Cell Biol 24, 10584-92
15572665   Curated Info

4

Levy C, Sonnenblick A, Razin E (2003) Role played by microphthalmia transcription factor phosphorylation and its Zip domain in its transcriptional inhibition by PIAS3. Mol Cell Biol 23, 9073-80
14645519   Curated Info

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