Ser73
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Home > Phosphorylation Site Page: > Ser73  -  MITF iso8 (mouse)

Site Information
PGSSAPNsPMAMLTL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450264

In vivo Characterization
Methods used to characterize site in vivo:
electrophoretic mobility shift ( 1 ) , immunoprecipitation ( 1 ) , mutation of modification site ( 1 , 2 , 3 , 4 , 7 ) , phospho-antibody ( 5 , 6 ) , western blotting ( 1 , 5 )
Disease tissue studied:
leukemia ( 5 ) , melanoma skin cancer ( 1 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 ) , 3T3 (fibroblast) ( 7 ) , A375P (melanocyte) ( 1 ) , heart ( 3 ) , mast-bone marrow ( 5 ) , MEF (fibroblast) ( 4 ) , Mel-Ab (melanocyte) ( 6 ) , melanocyte-skin [MITF (mouse), transgenic] ( 2 ) , neural crest ( 1 ) , RBL-2H3 (basophil) ( 5 ) , SK-MEL28 (melanocyte) ( 1 ) , skin ( 3 )

Upstream Regulation
Treatments:
IgE ( 5 ) , LPA ( 6 )

Downstream Regulation
Effects of modification on MITF iso8:
intracellular localization ( 1 ) , molecular association, regulation ( 7 ) , protein stabilization ( 1 )
Effects of modification on biological processes:
transcription, inhibited ( 7 )
Induce interaction with:
PIAS3 (human) ( 7 )

References 

1

Vu HN, et al. (2023) Novel mechanisms of MITF regulation and melanoma predisposition identified in a mouse suppressor screen. bioRxiv
37786677   Curated Info

2

Wen B, et al. (2010) Allele-specific genetic interactions between Mitf and Kit affect melanocyte development. Pigment Cell Melanoma Res 23, 441-7
20374522   Curated Info

3

Bauer GL, et al. (2009) The role of MITF phosphorylation sites during coat color and eye development in mice analyzed by bacterial artificial chromosome transgene rescue. Genetics 183, 581-94
19635938   Curated Info

4

Bismuth K, et al. (2008) An unstable targeted allele of the mouse Mitf gene with a high somatic and germline reversion rate. Genetics 178, 259-72
18202372   Curated Info

5

Sonnenblick A, Levy C, Razin E (2005) Immunological trigger of mast cells by monomeric IgE: effect on microphthalmia transcription factor, STAT3 network of interactions. J Immunol 175, 1450-5
16034081   Curated Info

6

Kim DS, et al. (2004) Effects of lysophosphatidic acid on melanogenesis. Chem Phys Lipids 127, 199-206
14726002   Curated Info

7

Levy C, Sonnenblick A, Razin E (2003) Role played by microphthalmia transcription factor phosphorylation and its Zip domain in its transcriptional inhibition by PIAS3. Mol Cell Biol 23, 9073-80
14645519   Curated Info

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