Ser211
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Home > Phosphorylation Site Page: > Ser211  -  SOX9 (human)

Site Information
FKALQADsPHsSSGM   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450957

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 2 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Disease tissue studied:
breast cancer ( 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
SMAD2 (human) ( 1 ) , SMAD3 (human) ( 1 )
Putative in vivo kinases:
P38A (human) ( 1 )
Treatments:
SB202190 ( 1 ) , SB203580 ( 1 ) , TGF-beta ( 1 )

Downstream Regulation
Effects of modification on SOX9:
protein stabilization ( 1 )
Effects of modification on biological processes:
transcription, induced ( 1 )

References 

1

Coricor G, Serra R (2016) TGF-β regulates phosphorylation and stabilization of Sox9 protein in chondrocytes through p38 and Smad dependent mechanisms. Sci Rep 6, 38616
27929080   Curated Info

2

Yi T, et al. (2014) Quantitative phosphoproteomic analysis reveals system-wide signaling pathways downstream of SDF-1/CXCR4 in breast cancer stem cells. Proc Natl Acad Sci U S A 111, E2182-90
24782546   Curated Info