Tyr340
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Home > Phosphorylation Site Page: > Tyr340  -  CD33 (human)

Site Information
EMDEELHyASLNFHG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450952

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 , 2 ) , phospho-antibody ( 1 , 2 )
Relevant cell line - cell type - tissue:
COS (fibroblast) ( 2 ) , U-937 (myeloid) ( 1 )

Upstream Regulation
Putative in vivo kinases:
Lck (human) ( 1 )
Phosphatases, in vitro:
SHP-1 (human) ( 2 ) , SHP-2 (human) ( 2 )
Treatments:
vanadate ( 1 )

Downstream Regulation
Effects of modification on CD33:
molecular association, regulation ( 1 , 2 )
Induce interaction with:
SHP-1 (human) ( 1 , 2 ) , SHP-2 (human) ( 1 , 2 )

References 

1

Paul SP, Taylor LS, Stansbury EK, McVicar DW (2000) Myeloid specific human CD33 is an inhibitory receptor with differential ITIM function in recruiting the phosphatases SHP-1 and SHP-2. Blood 96, 483-90
10887109   Curated Info

2

Taylor VC, et al. (1999) The myeloid-specific sialic acid-binding receptor, CD33, associates with the protein-tyrosine phosphatases, SHP-1 and SHP-2. J Biol Chem 274, 11505-12
10206955   Curated Info

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