Ser75
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Home > Phosphorylation Site Page: > Ser75  -  fumarase (human)

Site Information
yGAQTVRsTMNFkIG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 116533304

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 1 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Disease tissue studied:
pancreatic cancer ( 1 ) , pancreatic carcinoma ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
AMPKA1 (human) ( 1 )
Kinases, in vitro:
AMPKA1 (human) ( 1 )
Treatments:
glucose_starvation ( 1 )

Downstream Regulation
Effects of modification on fumarase:
molecular association, regulation ( 1 )
Effects of modification on biological processes:
cell growth, induced ( 1 ) , transcription, induced ( 1 )
Induce interaction with:
ATF-2 (human) ( 1 )

References 

1

Wang T, et al. (2017) O-GlcNAcylation of fumarase maintains tumour growth under glucose deficiency. Nat Cell Biol 19, 833-843
28628081   Curated Info