Ser64
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Home > Phosphorylation Site Page: > Ser64  -  FLI (human)

Site Information
KLEHLSVsHNNLTTL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 1163832400

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
breast cell-breast ( 1 ) , HEK293T (epithelial) ( 1 ) , MMTV-PyMT (breast cell) ( 1 )

Upstream Regulation
Regulatory protein:
Akt1 (human) ( 1 )
Putative in vivo kinases:
ULK1 (human) ( 1 )

Downstream Regulation
Effects of modification on FLI:
molecular association, regulation ( 1 )
Effects of modification on biological processes:
autophagy, induced ( 1 )
Inhibit interaction with:
KHDRBS1 (human) ( 1 )

Disease / Diagnostics Relevance
Relevant diseases:
breast cancer ( 1 )

References 

1

He JP, et al. (2018) Flightless-I blocks p62-mediated recognition of LC3 to impede selective autophagy and promote breast cancer progression. Cancer Res
29898994   Curated Info