Ser158
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.7.5
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Ser158  -  Snail2 (human)

Site Information
CDAQSRKsFSCKYCD   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 1162843400

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 2 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 2 ) , western blotting ( 2 )
Disease tissue studied:
liver cancer ( 1 ) , hepatocellular carcinoma ( 1 ) , prostate cancer ( 2 )
Relevant cell line - cell type - tissue:
HCCLM3 (hepatic) ( 1 ) , HEK293T (epithelial) ( 2 ) , Huh7 (hepatic) ( 1 ) , PC3 (prostate cell) ( 2 )

Upstream Regulation
Putative in vivo kinases:
PAK4 (human) ( 2 ) , PKACA (human) ( 1 )
Kinases, in vitro:
PAK4 (human) ( 2 )
Treatments:
cAMP_analog ( 2 ) , H-89 ( 1 ) , KT5720 ( 1 ) , PF3758309 ( 2 ) , SB431542 ( 2 ) , TGF-beta ( 2 )

Downstream Regulation
Effects of modification on Snail2:
activity, induced ( 2 ) , intracellular localization ( 2 ) , molecular association, regulation ( 1 ) , protein degradation ( 1 ) , protein stabilization ( 2 ) , ubiquitination ( 1 , 2 )
Effects of modification on biological processes:
carcinogenesis, induced ( 2 ) , carcinogenesis, inhibited ( 1 ) , cell motility, inhibited ( 1 ) , transcription, inhibited ( 2 )
Induce interaction with:
FBXO28 (human) ( 1 )

Disease / Diagnostics Relevance
Relevant diseases:
prostate cancer ( 2 )

References 

1

Qiao X, et al. (2023) FBXO28 suppresses liver cancer invasion and metastasis by promoting PKA-dependent SNAI2 degradation. Oncogene 42, 2878-2891
37596321   Curated Info

2

Park JJ, et al. (2018) The p21-activated kinase 4-Slug transcription factor axis promotes epithelial-mesenchymal transition and worsens prognosis in prostate cancer. Oncogene
29849120   Curated Info

Developed with grants from  NIH Logo and literature mining with Linguamatics  I2E Logo Creative Commons License PhosphoSite, created by Cell Signaling Technology is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License.

©2003-2024 Cell Signaling Technology, Inc.