Thr96
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Home > Phosphorylation Site Page: > Thr96  -  MBP iso5 (mouse)

Site Information
KNIVtPRtPPPSQGK   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450929

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 3 , 5 ) , mutation of modification site ( 2 ) , phospho-antibody ( 4 ) , western blotting ( 4 )
Disease tissue studied:
multiple sclerosis ( 4 )
Relevant cell line - cell type - tissue:
'brain, cerebellum' ( 3 ) , 'brain, cerebral cortex' ( 3 ) , 'brain, hippocampus, dentate gyrus' ( 3 ) , 'brain, midbrain' ( 3 ) , brain ( 4 , 5 ) , HEK293T (epithelial) ( 2 ) , N19 OLGs (oligodendrocyte) ( 2 )

Upstream Regulation
Treatments:
development ( 4 )

Downstream Regulation
Effects of modification on MBP iso5:
intracellular localization ( 2 ) , molecular association, regulation ( 1 , 2 ) , protein stabilization ( 1 )
Effects of modification on biological processes:
cytoskeletal reorganization ( 2 )
Inhibit interaction with:
Fyn (human) ( 2 )

References 

1

Vassall KA, et al. (2013) The Effects of Threonine Phosphorylation on the Stability and Dynamics of the Central Molecular Switch Region of 18.5-kDa Myelin Basic Protein. PLoS One 8, e68175
23861868   Curated Info

2

Smith GS, et al. (2012) Proline substitutions and threonine pseudophosphorylation of the SH3 ligand of 18.5-kDa myelin basic protein decrease its affinity for the Fyn-SH3 domain and alter process development and protein localization in oligodendrocytes. J Neurosci Res 90, 28-47
21887699   Curated Info

3

Trinidad JC, et al. (2008) Quantitative analysis of synaptic phosphorylation and protein expression. Mol Cell Proteomics 7, 684-96
18056256   Curated Info

4

DeBruin LS, Haines JD, Bienzle D, Harauz G (2006) Partitioning of myelin basic protein into membrane microdomains in a spontaneously demyelinating mouse model for multiple sclerosis. Biochem Cell Biol 84, 993-1005
17215885   Curated Info

5

Trinidad JC, et al. (2006) Comprehensive identification of phosphorylation sites in postsynaptic density preparations. Mol Cell Proteomics 5, 914-22
16452087   Curated Info