Tyr226
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Home > Phosphorylation Site Page: > Tyr226  -  Abl (mouse)

Site Information
KRNKPTIyGVSPNyD   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450303

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 3 , 6 , 8 ) , mass spectrometry (in vitro) ( 7 ) , mutation of modification site ( 3 , 9 , 10 ) , phospho-antibody ( 1 , 2 , 3 , 4 , 5 , 9 , 10 ) , western blotting ( 1 , 2 , 3 , 4 , 5 )
Disease tissue studied:
neuroblastoma ( 3 ) , testicular cancer ( 6 )
Relevant cell line - cell type - tissue:
'brain, embryonic' ( 5 ) , 'brain, midbrain' ( 1 ) , 'brain, substantia nigra' ( 3 ) , 293 (epithelial) ( 3 , 9 ) , 32D (myeloid) [BCR-ABL1 (human), transfection] ( 8 ) , 3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout] ( 9 ) , F9 (testicular) ( 6 ) , HEK293T (epithelial) ( 2 , 10 ) , MEF (fibroblast) [IGF1R (mouse)] ( 9 ) , prostate ( 4 ) , SH-SY5Y (neural crest) ( 3 )

Upstream Regulation
Regulatory protein:
AR (mouse) ( 4 ) , KRas (mouse) ( 4 )
Kinases, in vitro:
Abl (mouse) ( 7 )
Treatments:
etoposide ( 5 ) , GNF-5 ( 2 ) , IkT-148009 ( 1 ) , imatinib ( 10 ) , MPTP ( 1 ) , PDGF ( 9 ) , PP1 ( 9 )

Downstream Regulation
Effects of modification on Abl:
enzymatic activity, induced ( 2 , 7 , 9 , 10 ) , phosphorylation ( 2 )
Effects of modification on biological processes:
carcinogenesis, induced ( 2 ) , translation, induced ( 2 )

References 

1

Karuppagounder SS, et al. (2023) The c-Abl inhibitor IkT-148009 suppresses neurodegeneration in mouse models of heritable and sporadic Parkinson's disease. Sci Transl Med 15, eabp9352
36652533   Curated Info

2

McKernan CM, et al. (2022) ABL kinases regulate translation in HER2+ cells through Y-box-binding protein 1 to facilitate colonization of the brain. Cell Rep 40, 111268
36044842   Curated Info

3

Brahmachari S, et al. (2016) Activation of tyrosine kinase c-Abl contributes to α-synuclein-induced neurodegeneration. J Clin Invest 126, 2970-88
27348587   Curated Info

4

Drake JM, et al. (2012) Oncogene-specific activation of tyrosine kinase networks during prostate cancer progression. Proc Natl Acad Sci U S A 109, 1643-8
22307624   Curated Info

5

Nam C, Doi K, Nakayama H (2010) Etoposide induces G2/M arrest and apoptosis in neural progenitor cells via DNA damage and an ATM/p53-related pathway. Histol Histopathol 25, 485-93
20183801   Curated Info

6

Zhou J (2010) CST Curation Set: 9105; Year: 2010; Biosample/Treatment: cell line, F9/untreated; Disease: testicular cancer; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-102) Cat#: 9416
Curated Info

7

Tanis KQ, et al. (2003) Two distinct phosphorylation pathways have additive effects on Abl family kinase activation. Mol Cell Biol 23, 3884-96
12748290   Curated Info

8

Salomon AR, et al. (2003) Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry. Proc Natl Acad Sci U S A 100, 443-8
12522270   Curated Info

9

Furstoss O, et al. (2002) c-Abl is an effector of Src for growth factor-induced c-myc expression and DNA synthesis. EMBO J 21, 514-24
11847100   Curated Info

10

Brasher BB, Van Etten RA (2000) c-Abl has high intrinsic tyrosine kinase activity that is stimulated by mutation of the Src homology 3 domain and by autophosphorylation at two distinct regulatory tyrosines. J Biol Chem 275, 35631-7
10964922   Curated Info

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