Lys185

Site Information
RsEKAKLkAEILTCE SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 11539303

In vivo Characterization
Methods used to characterize site in vivo:	mutation of modification site ( 1 ) , western blotting ( 1 )
Disease tissue studied:	liver cancer ( 1 ) , hepatocellular carcinoma ( 1 )
Relevant cell line - cell type - tissue:	COS7 (fibroblast) ( 1 ) , Huh7 (hepatic) ( 1 )

Downstream Regulation
Effects of modification on PPAR-alpha:	molecular association, regulation ( 1 )
Effects of modification on biological processes:	transcription, inhibited ( 1 )
Induce interaction with:	N-CoR1 (human) ( 1 )

References
1	Pourcet B, et al. (2010) SUMOylation of human peroxisome proliferator-activated receptor alpha inhibits its trans-activity through the recruitment of the nuclear corepressor NCoR. J Biol Chem 285, 5983-92 19955185 Curated Info