Ser473

Site Information
RFPQGPPsQMGsPMG SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 11536858

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 , 2 , 3 , 4 , 5 , 6 )
Disease tissue studied:	HER2 positive breast cancer ( 1 ) , luminal A breast cancer ( 1 ) , luminal B breast cancer ( 1 ) , breast cancer, surrounding tissue ( 1 ) , breast cancer, triple negative ( 1 ) , cervical cancer ( 4 ) , cervical adenocarcinoma ( 4 ) , lymphoma ( 2 ) , Burkitt's lymphoma ( 2 ) , follicular lymphoma ( 2 ) , mantle cell lymphoma ( 2 )
Relevant cell line - cell type - tissue:	293 (epithelial) ( 6 ) , BJAB (B lymphocyte) ( 2 ) , breast ( 1 ) , FL-18 (B lymphocyte) ( 2 ) , FL-318 (B lymphocyte) ( 2 ) , HeLa S3 (cervical) ( 4 ) , HUES-7 ('stem, embryonic') ( 5 ) , JEKO-1 (B lymphocyte) ( 2 ) , Jurkat (T lymphocyte) ( 3 ) , NCEB-1 (B lymphocyte) ( 2 ) , Raji (B lymphocyte) ( 2 ) , SU-DHL-4 (B lymphocyte) ( 2 )

Upstream Regulation
Treatments:	nocodazole ( 4 )

References
1	Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62 27251275 Curated Info
2	Rolland D, et al. (2014) Global phosphoproteomic profiling reveals distinct signatures in B-cell non-Hodgkin lymphomas. Am J Pathol 184, 1331-42 24667141 Curated Info
3	Zhou J (2011) CST Curation Set: 12495; Year: 2011; Biosample/Treatment: cell line, Jurkat/calyculin_A & pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
4	Olsen JV, et al. (2010) Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci Signal 3, ra3 20068231 Curated Info
5	Van Hoof D, et al. (2009) Phosphorylation dynamics during early differentiation of human embryonic stem cells. Cell Stem Cell 5, 214-26 19664995 Curated Info
6	Gauci S, et al. (2009) Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal Chem 81, 4493-501 19413330 Curated Info