Tyr315
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Home > Phosphorylation Site Page: > Tyr315  -  endophilin A2 (human)

Site Information
QPSCKALyDFEPEND   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450745

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 )
Relevant cell line - cell type - tissue:
3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout] ( 1 ) , HEK293T (epithelial) ( 1 )

Upstream Regulation
Putative in vivo kinases:
FAK (human) ( 1 ) , Src (human) ( 1 )
Kinases, in vitro:
FAK (human) ( 1 ) , Src (human) ( 1 )

Downstream Regulation
Effects of modification on endophilin A2:
molecular association, regulation ( 1 )
Inhibit interaction with:
DYN1 (human) ( 1 )

References 

1

Wu X, Gan B, Yoo Y, Guan JL (2005) FAK-mediated src phosphorylation of endophilin A2 inhibits endocytosis of MT1-MMP and promotes ECM degradation. Dev Cell 9, 185-96
16054026   Curated Info

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