Thr120
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Home > Phosphorylation Site Page: > Thr120  -  MST1 (human)

Site Information
IIRLRNktLTEDEIA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 11496001

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 2 ) , immunoprecipitation ( 2 ) , mutation of modification site ( 2 , 3 ) , phospho-antibody ( 2 , 3 ) , western blotting ( 2 , 3 )
Disease tissue studied:
ovarian cancer ( 3 ) , prostate cancer ( 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
Akt1 (human) ( 2 , 3 )
Kinases, in vitro:
Akt1 (human) ( 2 , 3 )
Treatments:
dactolisib ( 2 ) , IGF-1 ( 3 ) , KU-0063794 ( 2 ) , LY294002 ( 2 ) , LY94002 ( 2 ) , serum_starvation ( 2 ) , temsirolimus ( 2 )

Downstream Regulation
Effects of modification on MST1:
enzymatic activity, inhibited ( 3 ) , intracellular localization ( 3 ) , molecular association, regulation ( 2 ) , phosphorylation ( 3 )
Effects of modification on biological processes:
apoptosis, altered ( 3 ) , carcinogenesis, induced ( 2 ) , cell growth, induced ( 2 ) , signaling pathway regulation ( 2 ) , transcription, induced ( 2 )
Inhibit interaction with:
AR (human) ( 2 )

Disease / Diagnostics Relevance
Relevant diseases:
ovarian cancer ( 3 ) , prostate cancer ( 2 )

References 

1

Mukhopadhyay NK, et al. (2014) Scaffold attachment factor B1 regulates the androgen receptor in concert with the growth inhibitory kinase MST1 and the methyltransferase EZH2. Oncogene 33, 3235-45
23893242   Curated Info

2

Collak FK, et al. (2012) Threonine-120 phosphorylation regulated by phosphoinositide-3-kinase/Akt and mammalian target of rapamycin pathway signaling limits the antitumor activity of mammalian sterile 20-like kinase 1. J Biol Chem 287, 23698-709
22619175   Curated Info

3

Yuan Z, et al. (2010) Phosphoinositide 3-kinase/Akt inhibits MST1-mediated pro-apoptotic signaling through phosphorylation of threonine 120. J Biol Chem 285, 3815-24
19940129   Curated Info