Thr258
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Home > Phosphorylation Site Page: > Thr258  -  PHB (mouse)

Site Information
LSRSRNItyLPAGQs   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 11139253

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 1 ) , mutation of modification site ( 2 ) , phospho-antibody ( 1 , 2 ) , western blotting ( 2 )
Disease tissue studied:
cervical cancer ( 2 ) , cervical squamous cell carcinoma ( 2 )
Relevant cell line - cell type - tissue:
CaSki (cervical) ( 2 ) , HeLa (cervical) ( 2 ) , liver ( 2 ) , lung ( 2 ) , SiHa (squamous) ( 2 ) , spermatozoa ( 1 )

Upstream Regulation
Putative in vivo kinases:
Akt1 (human) ( 1 , 2 )
Treatments:
anti-integrin_alpha9beta1 ( 2 ) , PIP3 ( 2 ) , wortmannin ( 1 )

Downstream Regulation
Effects of modification on PHB:
molecular association, regulation ( 2 )
Effects of modification on biological processes:
carcinogenesis, induced ( 2 ) , cell motility, induced ( 1 , 2 )
Induce interaction with:
RAF1 (mouse) ( 2 )

Disease / Diagnostics Relevance
Relevant diseases:
infertility ( 1 )

References 

1

Li XH, et al. (2020) Prohibitin (PHB) interacts with AKT in mitochondria to coordinately modulate sperm motility. Asian J Androl
32859869   Curated Info

2

Chiu CF, et al. (2012) Recombinant viral capsid protein VP1 suppresses migration and invasion of human cervical cancer by modulating phosphorylated prohibitin in lipid rafts. Cancer Lett 320, 205-14
22388104   Curated Info