Ser442
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Home > Phosphorylation Site Page: > Ser442  -  DYRK2 (human)

Site Information
IELLGMPsQKLLDAs   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 11489909

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
ATM (human) ( 1 )
Treatments:
adriamycin ( 1 )

Downstream Regulation
Effects of modification on DYRK2:
enzymatic activity, induced ( 1 )
Effects of modification on biological processes:
apoptosis, altered ( 1 )

References 

1

Taira N, et al. (2010) ATM augments nuclear stabilization of DYRK2 by inhibiting MDM2 in the apoptotic response to DNA damage. J Biol Chem 285, 4909-19
19965871   Curated Info