Ser565
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Home > Phosphorylation Site Page: > Ser565  -  FANCI (human)

Site Information
CsQSLSVsQVHVDVH   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 114809700

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry (in vitro) ( 1 ) , phospho-antibody ( 2 ) , western blotting ( 2 )
Disease tissue studied:
bone cancer ( 2 ) , ovarian cancer ( 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
USP1 (human) ( 2 )
Kinases, in vitro:
ATR (human) ( 1 )

Downstream Regulation
Effects of modification on FANCI:
molecular association, regulation ( 1 ) , ubiquitination ( 1 , 2 )
Induce interaction with:
DNA ( 1 )

References 

1

Tan W, van Twest S, Murphy VJ, Deans AJ (2020) ATR-Mediated FANCI Phosphorylation Regulates Both Ubiquitination and Deubiquitination of FANCD2. Front Cell Dev Biol 8, 2
32117957   Curated Info

2

Cheung RS, et al. (2017) Ubiquitination-Linked Phosphorylation of the FANCI S/TQ Cluster Contributes to Activation of the Fanconi Anemia I/D2 Complex. Cell Rep 19, 2432-2440
28636932   Curated Info