Tyr948

Site Information
KKSKQPLyssIVtVE SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 450715

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 )
Disease tissue studied:	bone cancer ( 4 ) , Ewing's sarcoma ( 4 ) , osteosarcoma ( 4 ) , lung cancer ( 3 , 5 ) , non-small cell lung cancer ( 3 ) , non-small cell lung adenocarcinoma ( 3 ) , neuroblastoma ( 1 , 7 ) , rhabdomyosarcoma ( 4 )
Relevant cell line - cell type - tissue:	293 (epithelial) [EphB2 (human), transfection] ( 6 ) , A673 (muscle cell) ( 4 ) , HeLa (cervical) ( 2 ) , MNNG-HOS (bone cell) ( 4 ) , NCI-H292 (pulmonary) ( 5 ) , PC9 (pulmonary) ( 3 ) , PC9-IR (pulmonary) ( 3 ) , RD18 (muscle cell) ( 4 ) , SKNFI (neural crest) ( 1 , 7 )

Upstream Regulation
Treatments:	ephrin_B1 ( 6 )

References
1	Palacios-Moreno J, et al. (2015) Neuroblastoma Tyrosine Kinase Signaling Networks Involve FYN and LYN in Endosomes and Lipid Rafts. PLoS Comput Biol 11, e1004130 25884760 Curated Info
2	Sharma K, et al. (2014) Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep 8, 1583-94 25159151 Curated Info
3	Yoshida T, et al. (2014) Tyrosine phosphoproteomics identifies both codrivers and cotargeting strategies for T790M-related EGFR-TKI resistance in non-small cell lung cancer. Clin Cancer Res 20, 4059-74 24919575 Curated Info
4	Bai Y, et al. (2012) Phosphoproteomics identifies driver tyrosine kinases in sarcoma cell lines and tumors. Cancer Res 72, 2501-11 22461510 Curated Info
5	Li J, et al. (2010) A chemical and phosphoproteomic characterization of dasatinib action in lung cancer. Nat Chem Biol 6, 291-9 20190765 Curated Info
6	Jørgensen C, et al. (2009) Cell-specific information processing in segregating populations of Eph receptor ephrin-expressing cells. Science 326, 1502-9 20007894 Curated Info
7	Stokes M (2006) CST Curation Set: 1764; Year: 2006; Biosample/Treatment: cell line, SKNFI/serum starved; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
8	MS Claus Jorgensen dataset-Toronto Curated Info