Tyr418
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Home > Phosphorylation Site Page: > Tyr418  -  IL2RB (human)

Site Information
LSGEDDAyCTFPSRD   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450884

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 , 2 )
Relevant cell line - cell type - tissue:
BaF3 ('B lymphocyte, precursor') ( 2 ) , COS (fibroblast) ( 2 ) , HT-2 (T lymphocyte) ( 1 )

Upstream Regulation
Kinases, in vitro:
Lck (human) ( 3 )

Downstream Regulation
Effects of modification on IL2RB:
molecular association, regulation ( 2 )
Effects of modification on biological processes:
apoptosis, inhibited ( 2 ) , cell growth, altered ( 2 )
Induce interaction with:
SHB (human) ( 2 )

References 

1

Lindemann MJ, et al. (2008) Differential regulation of the IL-17 receptor by gammac cytokines: inhibitory signaling by the phosphatidylinositol 3-kinase pathway. J Biol Chem 283, 14100-8
18348982   Curated Info

2

Lindholm CK (2002) IL-2 receptor signaling through the Shb adapter protein in T and NK cells. Biochem Biophys Res Commun 296, 929-36
12200137   Curated Info

3

Delespine-Carmagnat M, et al. (1999) Biochemical analysis of interleukin-2 receptor beta chain phosphorylation by p56(lck). FEBS Lett 447, 241-6
10214954   Curated Info

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