Tyr80
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Home > Phosphorylation Site Page: > Tyr80  -  ASE-1 (human)

Site Information
LAGKRHRyRVLSSCP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 11382803

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 1 , 2 ) , western blotting ( 1 , 2 )
Disease tissue studied:
cervical cancer ( 1 ) , cervical adenocarcinoma ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Treatments:
anti-CD3 ( 2 ) , serum_starvation ( 1 )

Downstream Regulation
Effects of modification on ASE-1:
molecular association, regulation ( 1 , 2 )
Effects of modification on biological processes:
transcription, altered ( 2 ) , transcription, induced ( 1 )
Inhibit interaction with:
CD3E (human) ( 2 )

References 

1

Panov KI, et al. (2006) RNA polymerase I-specific subunit CAST/hPAF49 has a role in the activation of transcription by upstream binding factor. Mol Cell Biol 26, 5436-48
16809778   Curated Info

2

Yamazaki T, et al. (1999) CAST, a novel CD3epsilon-binding protein transducing activation signal for interleukin-2 production in T cells. J Biol Chem 274, 18173-80
10373416   Curated Info