Ser184
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Home > Phosphorylation Site Page: > Ser184  -  coilin (human)

Site Information
NEEAKRKsPKKKEKC   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 11329300

In vivo Characterization
Methods used to characterize site in vivo:
[32P] ATP in vitro ( 4 ) , immunoprecipitation ( 1 ) , mass spectrometry ( 2 ) , microscopy-colocalization with upstream kinase ( 4 ) , mutation of modification site ( 5 ) , phospho-antibody ( 1 ) , phosphoamino acid analysis ( 4 ) , western blotting ( 1 )
Disease tissue studied:
breast cancer ( 1 ) , ovarian cancer ( 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
VRK1 (mouse) ( 1 , 4 )
Kinases, in vitro:
VRK1 (human) ( 4 ) , VRK2 (human) ( 4 )

Downstream Regulation
Effects of modification on coilin:
intracellular localization ( 5 )

References 

1

Cantarero L, et al. (2015) VRK1 regulates Cajal body dynamics and protects coilin from proteasomal degradation in cell cycle. Sci Rep 5, 10543
26068304   Curated Info

2

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

3

Shiromizu T, et al. (2013) Identification of missing proteins in the neXtProt database and unregistered phosphopeptides in the PhosphoSitePlus database as part of the Chromosome-centric Human Proteome Project. J Proteome Res 12, 2414-21
23312004   Curated Info

4

Sanz-GarcĂ­a M, et al. (2011) Substrate profiling of human vaccinia-related kinases identifies coilin, a Cajal body nuclear protein, as a phosphorylation target with neurological implications. J Proteomics 75, 548-60
21920476   Curated Info

5

Hebert MD, Matera AG (2000) Self-association of coilin reveals a common theme in nuclear body localization. Mol Biol Cell 11, 4159-71
11102515   Curated Info