Lys141

Site Information
TAWVFDDkYkRPGyG SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 11324636

In vivo Characterization
Methods used to characterize site in vivo:	immunoprecipitation ( 1 ) , mass spectrometry ( 1 , 2 , 3 , 4 ) , modification-specific antibody ( 1 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:	H9c2 (myoblast) ( 1 ) , HeLa (cervical) ( 2 ) , Jurkat (T lymphocyte) ( 3 , 4 ) , myocardium ( 1 )

Downstream Regulation
Effects of modification on biological processes:	apoptosis, induced ( 1 )

References
1	Prola A, et al. (2017) SIRT1 protects the heart from ER stress-induced cell death through eIF2α deacetylation. Cell Death Differ 24, 343-356 27911441 Curated Info
2	Weinert BT, et al. (2013) Lysine succinylation is a frequently occurring modification in prokaryotes and eukaryotes and extensively overlaps with acetylation. Cell Rep 4, 842-51 23954790 Curated Info
3	Mertins P, et al. (2013) Integrated proteomic analysis of post-translational modifications by serial enrichment. Nat Methods 10, 634-7 23749302 Curated Info
4	Choudhary C, et al. (2009) Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science 325, 834-40 19608861 Curated Info