Lys471
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Home > Acetylation Site Page: > Lys471  -  fascin (human)

Site Information
KVGGRYLkGDHAGVL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 11324304

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 1 , 3 ) , modification-specific antibody ( 1 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Disease tissue studied:
esophageal cancer ( 1 ) , esophageal carcinoma ( 1 ) , cancer, squamous cell carcinoma ( 1 )
Relevant cell line - cell type - tissue:
A549 (pulmonary) ( 3 ) , Kyse150 (esophageal) ( 1 ) , Kyse180 (esophageal) ( 1 ) , SHEEC ( 1 )

Downstream Regulation
Effects of modification on biological processes:
cell motility, inhibited ( 1 ) , cytoskeletal reorganization ( 1 )

Disease / Diagnostics Relevance
Relevant diseases:
ESCC ( 1 )

References 

1

Cheng YW, et al. (2021) P300/CBP-associated factor (PCAF)-mediated acetylation of Fascin at lysine 471 inhibits its actin-bundling activity and tumor metastasis in esophageal cancer. Cancer Commun (Lond) 41, 1398-1416
34555274   Curated Info

2

Beli P, et al. (2012) Proteomic Investigations Reveal a Role for RNA Processing Factor THRAP3 in the DNA Damage Response. Mol Cell 46, 212-25
22424773   Curated Info

3

Choudhary C, et al. (2009) Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science 325, 834-40
19608861   Curated Info

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