Lys414
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Home > Acetylation Site Page: > Lys414  -  cGAS (human)

Site Information
KDCLKLMkYLLEQLK   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 11322517

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 4 ) , mass spectrometry ( 3 , 4 , 5 ) , modification-specific antibody ( 2 ) , mutation of modification site ( 1 , 3 , 4 ) , western blotting ( 2 , 3 , 4 )
Disease tissue studied:
leukemia ( 4 ) , acute myelogenous leukemia ( 4 ) , fibrosarcoma of soft tissue ( 2 )
Relevant cell line - cell type - tissue:
bone marrow ( 4 ) , HEK293T (epithelial) ( 3 , 4 ) , HeLa (cervical) ( 4 ) , HFF1 (fibroblast) ( 3 ) , HT1080 (fibroblast) ( 2 ) , mononuclear-blood ( 4 ) , MV4-11 (macrophage) ( 5 ) , THP1 (myeloid) ( 4 )

Upstream Regulation
Regulatory protein:
Tip60 (human) ( 2 )
Treatments:
aspirin ( 4 ) , HT-DNA ( 4 ) , virus infection ( 2 ) , vorinostat ( 5 )

Downstream Regulation
Effects of modification on cGAS:
activity, inhibited ( 4 ) , enzymatic activity, inhibited ( 1 ) , protein conformation ( 1 )
Effects of modification on biological processes:
apoptosis, inhibited ( 3 )

References 

1

Guo J, et al. (2021) Conformational dynamics is critical for the allosteric inhibition of cGAS upon acetyl-mimic mutations. Phys Chem Chem Phys 23, 2154-2165
33438687   Curated Info

2

Song ZM, et al. (2020) KAT5 acetylates cGAS to promote innate immune response to DNA virus. Proc Natl Acad Sci U S A
32817552   Curated Info

3

Song B, et al. (2020) The DNA sensor cGAS is decorated by acetylation and phosphorylation modifications in the context of immune signaling. Mol Cell Proteomics
32345711   Curated Info

4

Dai J, et al. (2019) Acetylation Blocks cGAS Activity and Inhibits Self-DNA-Induced Autoimmunity. Cell 176, 1447-1460.e14
30799039   Curated Info

5

Choudhary C, et al. (2009) Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science 325, 834-40
19608861   Curated Info

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