Lys30
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Home > Acetylation Site Page: > Lys30  -  HINT1 (human)

Site Information
IRKEIPAkIIFEDDr   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 11320683

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 2 , 3 , 5 ) , modification-specific antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
colorectal cancer ( 1 ) , colorectal carcinoma ( 1 ) , melanoma skin cancer ( 1 )
Relevant cell line - cell type - tissue:
A375 (melanocyte) ( 1 ) , A549 (pulmonary) ( 5 ) , DLD1 (intestinal) ( 1 ) , HEK293T (epithelial) ( 1 ) , HeLa (cervical) ( 2 ) , Jurkat (T lymphocyte) ( 3 , 5 ) , SW480 (intestinal) ( 1 )

Upstream Regulation
Treatments:
vorinostat ( 5 )

Downstream Regulation
Effects of modification on HINT1:
molecular association, regulation ( 1 )
Effects of modification on biological processes:
carcinogenesis, induced ( 1 ) , cell growth, induced ( 1 )
Induce interaction with:
MITF (human) ( 1 )
Inhibit interaction with:
CTNNB1 (human) ( 1 )

References 

1

Jung TY, et al. (2020) Deacetylation by SIRT1 promotes the tumor-suppressive activity of HINT1 by enhancing its binding capacity for β-catenin or MITF in colon cancer and melanoma cells. Exp Mol Med 52, 1075-1089
32636443   Curated Info

2

Weinert BT, et al. (2013) Lysine succinylation is a frequently occurring modification in prokaryotes and eukaryotes and extensively overlaps with acetylation. Cell Rep 4, 842-51
23954790   Curated Info

3

Mertins P, et al. (2013) Integrated proteomic analysis of post-translational modifications by serial enrichment. Nat Methods 10, 634-7
23749302   Curated Info

4

Beli P, et al. (2012) Proteomic Investigations Reveal a Role for RNA Processing Factor THRAP3 in the DNA Damage Response. Mol Cell 46, 212-25
22424773   Curated Info

5

Choudhary C, et al. (2009) Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science 325, 834-40
19608861   Curated Info

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