Lys81
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.7.7
Powered by Cell Signaling Technology
Home > Acetylation Site Page: > Lys81  -  MAT2A (human)

Site Information
RAAVDYQkVVREAVk   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 11319857

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 1 , 2 ) , modification-specific antibody ( 1 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Disease tissue studied:
liver cancer ( 1 ) , hepatocellular carcinoma ( 1 ) , lung cancer ( 1 ) , non-small cell lung cancer ( 1 ) , lymphoma ( 1 )
Relevant cell line - cell type - tissue:
Chang liver (cervical) ( 1 ) , HEK293T (epithelial) ( 1 ) , HeLa (cervical) ( 1 ) , HepG2 (hepatic) ( 1 ) , Huh7 (hepatic) ( 1 ) , Jurkat (T lymphocyte) ( 2 ) , liver ( 1 ) , NCI-H1299 (pulmonary) ( 1 ) , U-937 (myeloid) ( 1 )

Upstream Regulation
Treatments:
DDATHF ( 1 ) , siRNA ( 1 ) , trichostatin_A ( 1 )

Downstream Regulation
Effects of modification on MAT2A:
methylation ( 1 ) , protein degradation ( 1 ) , ubiquitination ( 1 )
Effects of modification on biological processes:
carcinogenesis, inhibited ( 1 ) , cell growth, inhibited ( 1 )

Disease / Diagnostics Relevance
Relevant diseases:
hepatocellular carcinoma ( 1 )

References 

1

Yang HB, et al. (2015) Acetylation of MAT IIα represses tumour cell growth and is decreased in human hepatocellular cancer. Nat Commun 6, 6973
25925782   Curated Info

2

Choudhary C, et al. (2009) Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science 325, 834-40
19608861   Curated Info

Developed with grants from  NIH Logo and literature mining with Linguamatics  I2E Logo Creative Commons License PhosphoSite, created by Cell Signaling Technology is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License.

©2003-2024 Cell Signaling Technology, Inc.