Ser331
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Home > Phosphorylation Site Page: > Ser331  -  FANCD2 (human)

Site Information
KSKGRASsSGNQESS   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 11315004

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
Fanconi's anaemia ( 1 )
Relevant cell line - cell type - tissue:
BD180 (lymphoblast) ( 1 ) , EUFA143 ( 1 ) , EUFA868 ( 1 ) , GM6914 (fibroblast) ( 1 ) , HeLa (cervical) ( 1 ) , HSC72 (lymphoblast) ( 1 ) , PD20 ( 1 )

Upstream Regulation
Putative in vivo kinases:
Chk1 (human) ( 1 )
Kinases, in vitro:
Chk1 (human) ( 1 )
Treatments:
mitomycin_C ( 1 ) , SB218078 ( 1 )

Downstream Regulation
Effects of modification on FANCD2:
molecular association, regulation ( 1 ) , ubiquitination ( 1 )
Induce interaction with:
BRCA2 (human) ( 1 )

References 

1

Zhi G, et al. (2009) Fanconi anemia complementation group FANCD2 protein serine 331 phosphorylation is important for fanconi anemia pathway function and BRCA2 interaction. Cancer Res 69, 8775-83
19861535   Curated Info