Tyr581
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Home > Phosphorylation Site Page: > Tyr581  -  PDGFRB (human)

Site Information
SDGHEyIyVDPMQLP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447519

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 4 ) , immunoprecipitation ( 4 ) , mutation of modification site ( 2 , 3 , 4 , 5 ) , phospho-antibody ( 1 ) , western blotting ( 1 , 2 )
Relevant cell line - cell type - tissue:
BaF3 ('B lymphocyte, precursor') [PDGFRB (human)] ( 3 ) , bone marrow [PDGFRB (human)] ( 3 ) , COS (fibroblast) ( 2 ) , HEK293T (epithelial) ( 2 ) , HepG2 (hepatic) ( 4 ) , PAE (endothelial) ( 1 , 5 )

Upstream Regulation
Kinases, in vitro:
PDGFRB (human) ( 4 )
Treatments:
PDGF ( 1 , 4 ) , vanadate ( 4 )

Downstream Regulation
Effects of modification on PDGFRB:
enzymatic activity, induced ( 2 , 4 , 5 ) , molecular association, regulation ( 4 ) , phosphorylation ( 5 )
Effects of modification on biological processes:
cell growth, altered ( 3 )
Induce interaction with:
PIK3R1 (human) ( 4 ) , PLCG1 (human) ( 4 ) , RASA1 (human) ( 4 )

References 

1

Wardega P, Heldin CH, Lennartsson J (2010) Mutation of tyrosine residue 857 in the PDGF beta-receptor affects cell proliferation but not migration. Cell Signal 22, 1363-8
20494825   Curated Info

2

Paukku K, et al. (2000) Platelet-derived growth factor (PDGF)-induced activation of signal transducer and activator of transcription (Stat) 5 is mediated by PDGF beta-receptor and is not dependent on c-src, fyn, jak1 or jak2 kinases. Biochem J 345 Pt 3, 759-66
10642538   Curated Info

3

Tomasson MH, et al. (2000) Fatal myeloproliferation, induced in mice by TEL/PDGFbetaR expression, depends on PDGFbetaR tyrosines 579/581. J Clin Invest 105, 423-32
10683371   Curated Info

4

Baxter RM, Secrist JP, Vaillancourt RR, Kazlauskas A (1998) Full activation of the platelet-derived growth factor beta-receptor kinase involves multiple events. J Biol Chem 273, 17050-5
9642269   Curated Info

5

Hooshmand-Rad R, Yokote K, Heldin CH, Claesson-Welsh L (1998) PDGF alpha-receptor mediated cellular responses are not dependent on Src family kinases in endothelial cells. J Cell Sci 111 ( Pt 5), 607-14
9454734   Curated Info