Ser481
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Home > Phosphorylation Site Page: > Ser481  -  ATP7B (human)

Site Information
ILAKsPQsTRAVAPQ   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 11267006

In vivo Characterization
Methods used to characterize site in vivo:
[32P] ATP in vitro ( 1 ) , mass spectrometry ( 2 , 3 ) , mass spectrometry (in vitro) ( 3 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Disease tissue studied:
hepatocellular carcinoma ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Kinases, in vitro:
PRKD1 (human) ( 1 )
Treatments:
CID755673 ( 1 ) , copper ( 3 ) , phorbol_ester ( 1 )

Downstream Regulation
Effects of modification on ATP7B:
intracellular localization ( 1 ) , protein stabilization ( 1 )

References 

1

Pilankatta R, Lewis D, Inesi G (2011) Involvement of protein kinase D in expression and trafficking of ATP7B (copper ATPase). J Biol Chem 286, 7389-96
21189263   Curated Info

2

Kettenbach AN, et al. (2011) Quantitative phosphoproteomics identifies substrates and functional modules of aurora and polo-like kinase activities in mitotic cells. Sci Signal 4, rs5
21712546   Curated Info

3

Pilankatta R, Lewis D, Adams CM, Inesi G (2009) High yield heterologous expression of wild-type and mutant Cu+-ATPase (ATP7B, Wilson disease protein) for functional characterization of catalytic activity and serine residues undergoing copper-dependent phosphorylation. J Biol Chem 284, 21307-16
19520855   Curated Info