Ser1453
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Home > Phosphorylation Site Page: > Ser1453  -  ATP7B (human)

Site Information
DDDGDKWsLLLNGRD   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 11267005

In vivo Characterization
Methods used to characterize site in vivo:
[32P] ATP in vitro ( 3 ) , mass spectrometry ( 1 , 2 , 4 ) , mass spectrometry (in vitro) ( 4 ) , mutation of modification site ( 3 ) , western blotting ( 3 )
Disease tissue studied:
breast cancer ( 2 ) , breast ductal carcinoma ( 2 ) , luminal A breast cancer ( 1 ) , hepatocellular carcinoma ( 3 )
Relevant cell line - cell type - tissue:
breast ( 1 , 2 ) , COS (fibroblast) ( 3 , 4 ) , Hep-G2/C3A (hepatic) ( 3 )

Upstream Regulation
Kinases, in vitro:
PRKD1 (human) ( 3 )
Treatments:
CID755673 ( 3 ) , copper ( 4 ) , phorbol_ester ( 3 )

Downstream Regulation
Effects of modification on ATP7B:
intracellular localization ( 3 ) , protein stabilization ( 3 )

References 

1

Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62
27251275   Curated Info

2

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

3

Pilankatta R, Lewis D, Inesi G (2011) Involvement of protein kinase D in expression and trafficking of ATP7B (copper ATPase). J Biol Chem 286, 7389-96
21189263   Curated Info

4

Pilankatta R, Lewis D, Adams CM, Inesi G (2009) High yield heterologous expression of wild-type and mutant Cu+-ATPase (ATP7B, Wilson disease protein) for functional characterization of catalytic activity and serine residues undergoing copper-dependent phosphorylation. J Biol Chem 284, 21307-16
19520855   Curated Info